Effects of adaptive servoventilation on ventricular arrhythmias in heart failure patients with either obstructive or central sleep apnea – a substudy of the ADVENT-HF trial

Project start
Institution: University Hospital Regensburg, Department of Internal Medicine II
Applicant: Prof. Dr. Michael Arzt
EKFS funding line: Key Project

Non-pharmacological treatment of comorbidities of heart failure such as sleep apnea may have an effect on ventricular arrhythmias, cardiac function and prognosis. Half of the patients with heart failure suffer from obstructive or central sleep apnea. Therefore, the aim of this project is, to test whether treatment of sleep apnea with adaptive servoventilation reduces the burden of nocturnal ventricular arrhythmias compared to the control group. Therefore, we perform a substudy of the large-scale ongoing investigator initated randomized controlled ADVENT-HF trial (850 participants). The substudy includes a detailed analysis of the nocturnal electrocardiograms before and after treatment initiation. Results will be relevant for future guidelines for the management of heart failure patients.

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