Staphylococcus aureus is a leading bacterial pathogen that frequently causes soft tissue infections, sepsis and endocarditis. Despite the fact that antimicrobial resistance often associates with poor clinical outcomes, high morbidity and mortality rates in humans have also been assigned to the unique ability of S. aureus to escape host immune cell responses. To address this challenge for public health, this work program seeks to discover new immune evasion strategies of S. aureus that significantly promote staphylococcal survival in deep-seated abscesses and during acute blood stream infection. Discoveries in this area may aid in the development of new therapeutic agents to combat infections caused by methicillin-resistant S. aureus (MRSA) or other drug-resistant microbes.
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