A combined brain stimulation technique of electrical stimulation of basal ganglia structures through a deep brain stimulator (DBS) and transcranial magnetic stimulation of brain surface areas that control movement preparation and execution will be applied to X-linked dystonia Parkinson (XDP) patients. This approach allows drawing direct conclusions about the interaction of those brain motor regions and their contribution to the dystonic symptoms. XDP, in which the disease cause is well defined and shows a fast and robust DBS treatment response, functions as a model disease for idiopathic dystonia. Longitudinal study design and comparison with other genetic forms of dystonia with slower and less effective DBS response will help to draw conclusions about DBS function and optimization.

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