Cancer
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Deciphering the role of specific phosphatases in human lymphoma

Institution: University Hospital Frankfurt, Department of Hematology and Oncology
Applicant: Sebastian Scheich
Funding line:
First and Second Applications
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Aggressive lymphomas are cancer types that originate from a subtype of white blood cells, the lymphocytes. Diffuse large B-cell lymphoma is the most common subtype of lymphoma and is characterized by an aggressive clinical course. In the preliminary work, the researchers identified proteins responsible for regulating phosphorylation sites (phosphatases) that drive lymphoma growth. In the present project, the role of these specific phosphatases in tumor growth will be elucidated using modern biochemical and molecular biological methods, with the aim of ultimately finding new therapeutic options for this aggressive form of cancer.

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