As we age, the immune system becomes less effective, partly because the thymus - the central organ for maturation of the body’s most important immune cells - loses its function. This increases the risk of infections and cancer. The goal of this project is to temporarily transform the liver into a "replacement factory" that, with the help of mRNA messengers, produces key thymus-derived signals. In this way, immune cells in the body can be selectively strengthened without the need to regenerate the thymus itself. This innovative strategy could help overcome age-related immune deficiencies—with important implications for cancer therapy, vaccine efficacy, and combating infectious diseases in our aging society.

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