Multiple sclerosis (MS) is a common neuroinflammatory disorder is driven by a dysregulated immune response directed against central nervous system self-antigens, which results in the formation of inflammatory lesions. To prevent attack by auto-aggressive T cells and to resolve inflammation within the tissue, the body's natural mechanisms of tolerance induction are of great importance. The research group's data has provided first evidence that activation of rare neuronal cell populations located within the brainstem by peripheral cues has a profound immunomodulatory effect on pro-inflammatory T cell responses. Deciphering the underlying mechanisms may be key to develop novel therapeutic strategies to dampen neuroinflammation in MS patients.

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