Human cells can remove themselves when they become a danger for neighboring cells or even the entire organisms by a program, termed apoptosis. In healthy human beings, apoptosis contains infections and severe diseases, such as cancer. The development of a tumor requires misregulation of apoptosis. Among other characteristic properties, tumor cells often show an altered metabolism of the sugar glucose. We have preliminary evidence for the involvement of the enzymes funneling glucose into the metabolism, so called hexokinases, being involved in the inhibition of apoptosis. This activity might link two central changes that cause a cell to be a tumor cell. We investigate how hexokinases inhibit apoptosis and how this regulation is influenced by or influences the glucose metabolism.