Autoimmune kidney diseases called glomerulonephritides (GNs) are a common cause of chronic kidney disease (CKD). These diseases primarily affect young patients and often show a particularly aggressive course with rapid loss of kidney function. GNs are responsible for around 1/6 of the 80,000 new dialysis patients annually in the EU. Autoantibodies against kidney proteins play a pathogenic role in many of these diseases. The overarching goal of this project is to better understand the action of autoantibodies in the kidney and therefore enable more specific therapies to treat autoimmune kidney diseases. Therapies mainly focus on the clearance of pathogenic autoantibodies and the elimination of autoreactive B cells.

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