Currently funded projects

Project plan to obtain, propagate, and transplant  primary human muscle stem in an autologous setting.

Patient-derived muscle stem cells for the treatment of muscle wasting and muscular defects

Institution: Charité Campus Buch, Experimental and Clinical Research Center, Lindenberger Weg 80, 13125 Berlin
Applicant: Prof. Dr. Simone Spuler, Charité Universitätsmedizin Berlin und Max-Delbrück Zentrum für Molekulare Medizin

Monoclonal antibodies, like 6A10 targeting the protein CA12, can be generated by extracellular vesicles. These antibodies are specific for tumor-associated factors and can therefore bind to tumor cells.

Preclinical Evaluation of a proprietary antibody for cancer treatment

Institution: Helmholtz Zentrum München, Deutsches Zentrum für Gesundheit und Umwelt (HMGU) und Klinikum der Universität München (KUM)
Applicant: Prof. Dr. Reinhard Zeidler

The dual farnesoid X receptor and soluble epoxide hydrolase modulator (FXRA/sEHi) was designed by rational pharmacophore fusion and is currently evaluated for (synergistic) efficacy and improved safety in preclinical studies.

Preclinical characterization of an innovative dual FXR/sEH modulator as experimental drug to treat non-alcoholic steatohepatitis

Institution: Institut für Pharmazeutische Chemie, Johann Wolfgang Goethe-Universität Frankfurt, Max-von-Laue Straße 9 , 60438 Frankfurt/Main
Applicant: Dr. phil. nat. Daniel Merk, Johann Wolfgang Goethe-Universität Frankfurt

The SPIONDEX iron oxide oxide nanoparticles are synthesized at SEON and extensively characterized and tested toxicologically, both in vitro and in vivo. They will be used as contrast agents in magnetic resonance imaging.

Safe Contrast Agents for Magnetic Resonance Imaging (MRI)

Institution: Sektion für Experimentelle Onkologie und Nanomedizin (SEON), Else Kröner-Fresenius-Stiftungsprofessur für Nanomedizin, Hals-Nasen-Ohrenklinik, Kopf- und Halschirurgie, Universitätsklinikum Erlangen, Uni-Kl. Erlangen
Applicant: Prof. Dr. med. Christoph Alexiou

Dystrophin ∆52 lacks exon 52, which prohibits its expression as a protein. Additional excision of exon 51 restores the reading frame and expression of an internally truncated Dystrophin protein ∆51-52.

Genome editing as therapeutic approach to Duchenne´s muscle dystrophy

Institution: Klinikum Rechts der Isar, TU München
Applicant: Prof. Dr. med. Christian Kupatt

Breeding of telocytes in cell culture. Telocytes will be characterized using biological methods, and cells with the best properties will be amplified by cultivation. Finally, “therapeutic telocytes” shall be used in the clinic.

Development of therapeutic cardiac telocytes to prevent heart failure after acute myocardial infarction

Institution: Kerckhoff-Klinik, Bad Nauheim
Applicant: PD Dr. Manfred Richter

Ms. Kosanke preparing the real-time PCR reaction for the fast and accurate identification of pathogens causing dermatophytosis

A central service for the fast, accurate and sensitive detection of pathogens in suspected cases of dermatophytosis

Institution: Charité Berlin
Applicant: Prof. Dr. Yvonne Gräser

Syringe in lieu of mosquito: malaria sporozoites are prepared for the experimental infection.

Evaluation of the potential antimalarial effect of ivermectin: a controlled human malaria infection trial – PREMIVER (PREvention of Malaria with IVERmectin)

Institution: Institut für Tropenmedizin, Reisemedizin, Humanparasitologie, Universitätsklinikum Tübingen
Applicant: Prof. Dr. Peter G. Kremsner

CCL25 based regeneration for treatment of osteoarthritis. Concept of product design and application.

CCL25-based regeneration for treatment of osteoarthritis – Safety study on the biological factor CCL25

Institution: Labor für Tissue Engineering, Klinik für Rheumatologie und Klinische Immunologie, Charité – Universitätsmedizin Berlin
Applicant: Dr. rer. nat. Michael Sittinger

Optical Mapping of an intact Langendorff-perfused rabbit heart.

cardioLEAP - Low-Energy Anti-Fibrillation Pacing

Institution: Max-Planck-Institut für Dynamik und Selbstorganisation (MPIDS), Göttingen
Applicant: Prof. Dr. Stefan Luther