May 2024: $$ Multimodal layer modelling reveals in vivo pathology in amyotrophic lateral sclerosis

Journal: Brain 2024
Author: Esther Kühn
Institution: Hertie Institute for Clinical Brain Research

Project description: 

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease involving the motor system, which often leads to the death of  the Patient within a few years. The neuronal disease mechanisms of ALS are often described based on animal models or investigations of dead human brain tissue. Here, the team used novel methodology, ultra-high field magnetic resonance imaging (7T-MRI), to gain a more precise insight on the acute disease state of the primary motor cortex (M1) in the living patient as well as its development over time. They show that a single 7T-MRI scan can be used to detect affected brain tissue in different layers of M1, and uncovers its development over time. The team could use this data to develop individualized disease profiles of M1 in living patients, which shows the potential of ultra-high field MRI for personalized diagnostics and therapy.


Northall A, Doehler J, Weber M, Tellez I, Petri S, Prudlo J, Vielhaber S, Schreiber S, Kuehn E (2024) Multimodal layer modelling reveals in vivo pathology in amyotrophic lateral sclerosis. Brain 147(3):1087-1099. 



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